Reduction of cortical pyramidal neuron excitability by the action of phenytoin on persistent Na+ current.

Abstract

We examined the effect of the anticonvulsant phenytoin (PT) (20-200 microM) on the persistent Na+ current (INaP), INaP-dependent membrane potential responses and repetitive firing in layer 5 pyramidal neurons in a slice preparation of rat sensorimotor cortex. INaP measured directly with voltage-clamp was reduced in a concentration-dependent manner with an… (More)

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