Reduction of cortical TrkA but not p75NTR protein in early‐stage Alzheimer's disease

@article{Counts2004ReductionOC,
  title={Reduction of cortical TrkA but not p75NTR protein in early‐stage Alzheimer's disease},
  author={Scott E. Counts and Muhammad Nadeem and Joanne Wuu and Stephen D. Ginsberg and H. Uri Saragovi and Elliott J. Mufson},
  journal={Annals of Neurology},
  year={2004},
  volume={56}
}
Degeneration of cholinergic nucleus basalis (NB) cortical projection neurons is associated with cognitive decline in late‐stage Alzheimer's disease (AD). NB neuron survival is dependent on coexpression of the nerve growth factor (NGF) receptors p75NTR and TrkA, which bind NGF in cortical projection sites. We have shown previously a significant reduction of NB perikarya expressing p75NTR and TrkA protein during the early stages of AD. Whether there is a concomitant reduction in cortical levels… 
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Down regulation of trk but not p75NTR gene expression in single cholinergic basal forebrain neurons mark the progression of Alzheimer's disease
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The role of nerve growth factor receptors in cholinergic basal forebrain degeneration in prodromal Alzheimer disease.
Dysfunction of nerve growth factor (NGF) and its high (TrkA) and low (p75NTR) affinity receptors has been suggested to underlie the selective degeneration of the nucleus basalis (NB) cholinergic
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TLDR
The concept that from a neurotrophic pathobiologic perspective, MCI is already early AD is supported, as there is a shift in cholinotrophic molecular events in MCI and early AD which may lead to cell dysfunction and eventual cell death over the course of the disease.
Progression of age‐associated cognitive impairment correlates with quantitative and qualitative loss of TrkA receptor protein in nucleus basalis and cortex
  • H. Saragovi
  • Biology, Psychology
    Journal of neurochemistry
  • 2005
A direct correlation between disease progression and reduced expression of TrkA receptor in cholinergic neurons has been documented in neurocognitive pathologies including Alzheimer's disease. We
Shift in the Balance of TRKA and ProNGF in Prodromal Alzheimer ’s Disease
TLDR
To better understand the roles of NGF, proNGF, the common neurotrophin receptor p75, and the high-affinity trkA receptor in basal cortical dysfunction and their relation to cognitive impairment, postmortem brain tissue from subjects during the prodromal stages of AD is examined.
Cholinergic system during the progression of Alzheimer’s disease: therapeutic implications
TLDR
Drugs treating the multiple pathologies and clinical symptoms in AD (e.g., M1 cholinoceptor and/or galaninergic drugs) should be considered for a more comprehensive treatment approach for cholinergic dysfunction.
Increased Matrix Metalloproteinase 9 Activity in Mild Cognitive Impairment
TLDR
Examining human frontal and parietal cortex tissues from aged subjects with a clinical diagnosis of AD, mild cognitive impairment, or no cognitive impairment suggested that a reduction in mNGF as a consequence of MMP-9-mediated degradation may in part underlie the pathogenesis of cognitive deficits in mild Cognitive impairment and AD.
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