Reduction of concentration of HIV-1 in semen after treatment of urethritis: implications for prevention of sexual transmission of HIV-1

@article{Cohen1997ReductionOC,
  title={Reduction of concentration of HIV-1 in semen after treatment of urethritis: implications for prevention of sexual transmission of HIV-1},
  author={Myron S. Cohen and I. Hoffman and R. Royce and P. Kazembe and J. Dyer and C. Daly and D. Zimba and P. Vernazza and M. Maida and S. Fiscus and J. Eron},
  journal={The Lancet},
  year={1997},
  volume={349},
  pages={1868-1873}
}
BACKGROUND Transmission of HIV-1 is predominantly by heterosexual contact in sub-Saharan Africa, where sexually transmitted diseases (STDs) are also common. Epidemiological studies suggest that STDs facilitate transmission of HIV-1, but the biological mechanism remains unclear. We investigated the hypothesis that STDs increase the likelihood of transmission of HIV-1 through increased concentration of the virus in semen. METHODS HIV-1 RNA concentrations were measured in seminal and blood… Expand
High levels of human immunodeficiency virus type 1 in blood and semen of seropositive men in sub-Saharan Africa.
Baeten Genital HIV-1 RNA Predicts Risk of Heterosexual HIV-1 Transmission
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