Reduction of cerebral infarct size by non-competitive AMPA antagonists in rats subjected to permanent and transient focal ischemia

@article{Matucz2004ReductionOC,
  title={Reduction of cerebral infarct size by non-competitive AMPA antagonists in rats subjected to permanent and transient focal ischemia},
  author={{\'E}va Matucz and Krisztina M{\'o}ricz and G{\'a}bor Gigler and Annam{\'a}ria Sim{\'o} and G{\'a}bor Sz{\'e}n{\'a}si},
  journal={Brain Research},
  year={2004},
  volume={1019},
  pages={210-216}
}
Antagonists of 2-amino-3(3-hydroxy-5-methyl-4-isoxazolyl) propionic acid (AMPA) receptors can considerably reduce brain damage after cerebral ischemia, but effectiveness of selective AMPA antagonists has been questioned recently. Therefore, we evaluated the antiischemic efficacy of [+/-]-7-acetyl-5-[4-aminophenyl]-7,8-dihydro-8-cyano-8-methyl-9H-1,3-dioxolo-[4,5-h]-2,3-benzodiazepine (EGIS-8332) and GYKI 53405, two selective, non-competitive AMPA antagonists in two rat models of focal cerebral… CONTINUE READING

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