Reduction of ceramide de novo synthesis in solid tissues changes sphingolipid levels in rat plasma, erythrocytes and platelets.

  title={Reduction of ceramide de novo synthesis in solid tissues changes sphingolipid levels in rat plasma, erythrocytes and platelets.},
  author={Agnieszka Urszula Błachnio-Zabielska and Marcin Baranowski and Beata W{\'o}jcik and Janusz G{\'o}rski},
  journal={Advances in medical sciences},
  volume={61 1},
PURPOSE De novo sphingolipid synthesis does not occur in plasma, erythrocytes and platelets. The purpose of the study was to examine the effect of inhibition of sphingolipid synthesis in solid tissues on the level of the following bioactive sphingolipids: sphinganine, ceramide, sphingosine and sphingosine 1-phosphate in plasma, erythrocytes and platelets. MATERIAL/METHODS The experiments were carried out on male Wistar rats. Myriocin was used to inhibit serine palmitoyltransferase activity… Expand
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