Reduction of central nervous system reperfusion injury in rabbits using doxycycline treatment.

@article{Clark1994ReductionOC,
  title={Reduction of central nervous system reperfusion injury in rabbits using doxycycline treatment.},
  author={Wayne M. Clark and F A Calcagno and W. Gabler and Justine R Smith and Bruce M. Coull},
  journal={Stroke},
  year={1994},
  volume={25 7},
  pages={
          1411-5; discussion 1416
        }
}
BACKGROUND AND PURPOSE Activated leukocytes appear to potentiate central nervous system reperfusion injury, and agents that block leukocyte adhesion have shown neuroprotective efficacy in experimental models. Doxycycline, a tetracycline antibiotic, inhibits leukocyte function in vitro, presumably through divalent cation binding. We used a model of focal central nervous system reperfusion injury to determine the efficacy of doxycycline treatment in preserving neurological function. METHODS… CONTINUE READING

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