Reduction of caspase-8 and -9 cleavage is associated with increased c-FLIP and increased binding of Apaf-1 and Hsp70 after neonatal hypoxic/ischemic injury in mice overexpressing Hsp70.

@article{Matsumori2006ReductionOC,
  title={Reduction of caspase-8 and -9 cleavage is associated with increased c-FLIP and increased binding of Apaf-1 and Hsp70 after neonatal hypoxic/ischemic injury in mice overexpressing Hsp70.},
  author={Y. Matsumori and F. Northington and Shwuhuey M. Hong and T. Kayama and R. Sheldon and Z. Vexler and D. Ferriero and P. Weinstein and J. Liu},
  journal={Stroke},
  year={2006},
  volume={37 2},
  pages={
          507-12
        }
}
  • Y. Matsumori, F. Northington, +6 authors J. Liu
  • Published 2006
  • Medicine
  • Stroke
  • BACKGROUND AND PURPOSE Caspase-8 and caspase-9 are essential proteases of the extrinsic and intrinsic apoptotic pathways, respectively. We investigated whether neuroprotection associated with overexpression of heat-shock protein 70 (Hsp70), a natural cellular antiapoptotic protein, is mediated by caspase-8 and caspase-9 signaling in the neonatal mouse brain after hypoxia/ischemia (H/I) injury. METHODS Postnatal day 7 transgenic mice overexpressing rat Hsp70 (Hsp70 Tg) and their wild-type (Wt… CONTINUE READING
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