Reduction of caspase-8 and -9 cleavage is associated with increased c-FLIP and increased binding of Apaf-1 and Hsp70 after neonatal hypoxic/ischemic injury in mice overexpressing Hsp70.

@article{Matsumori2006ReductionOC,
  title={Reduction of caspase-8 and -9 cleavage is associated with increased c-FLIP and increased binding of Apaf-1 and Hsp70 after neonatal hypoxic/ischemic injury in mice overexpressing Hsp70.},
  author={Yasuhiko Matsumori and Frances J. Northington and Shwuhuey M. Hong and Takamasa Kayama and R. Ann Sheldon and Zinaida S. Vexler and Donna M. Ferriero and Philip R. Weinstein and Jialing Liu},
  journal={Stroke},
  year={2006},
  volume={37 2},
  pages={
          507-12
        }
}
BACKGROUND AND PURPOSE Caspase-8 and caspase-9 are essential proteases of the extrinsic and intrinsic apoptotic pathways, respectively. We investigated whether neuroprotection associated with overexpression of heat-shock protein 70 (Hsp70), a natural cellular antiapoptotic protein, is mediated by caspase-8 and caspase-9 signaling in the neonatal mouse brain after hypoxia/ischemia (H/I) injury. METHODS Postnatal day 7 transgenic mice overexpressing rat Hsp70 (Hsp70 Tg) and their wild-type (Wt… CONTINUE READING

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