Reduction of bleomycin induced lung fibrosis by candesartan cilexetil, an angiotensin II type 1 receptor antagonist.

@article{Otsuka2004ReductionOB,
  title={Reduction of bleomycin induced lung fibrosis by candesartan cilexetil, an angiotensin II type 1 receptor antagonist.},
  author={Mitsuo Otsuka and Hiroshi Takahashi and Miwa Shiratori and Hirofumi Chiba and Sinji Abe},
  journal={Thorax},
  year={2004},
  volume={59 1},
  pages={31-8}
}
BACKGROUND Signalling of angiotensin II via angiotensin II type 1 receptor (AT1) promotes cardiac and renal fibrosis, but its role in lung fibrosis is little understood. Using a rat bleomycin (BLM) induced model of pulmonary fibrosis, we examined the expression of AT1 in the lung and the effect of an AT1 antagonist on pulmonary fibrosis. METHODS Adult male Sprague-Dawley rats were given 0.3 mg/kg BLM intratracheally. Two days earlier they had received 10 mg/kg/day of the AT1 antagonist… CONTINUE READING

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