Reduction of bacterial resistance with inhaled antibiotics in the intensive care unit.


RATIONALE Multidrug-resistant organisms (MDRO) are the dominant airway pathogens in the intensive care unit (ICU) and present a major treatment challenge to intensivists. Aerosolized antibiotics (AA) result in airway concentrations of drug 100-fold greater than the minimal inhibitory concentration of most bacteria including MDRO. These levels, without… (More)
DOI: 10.1164/rccm.201312-2161OC


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