Reduction of background activities by introduction of a diester linkage between antibody and a chelate in radioimmunodetection of tumor.

Abstract

A diester linkage was added between monoclonal anti-melanoma antibody 96.5 and a diethylenetriaminepentaacetic acid derivative to test if a tumor-to-blood and -to-organ ratio of the injected antibody in nude mice with human melanoma FEM XII xenografts could be increased by the addition of the readily cleavable linkage. Compared to the 111In-labeled antibody… (More)

Topics

Cite this paper

@article{Paik1989ReductionOB, title={Reduction of background activities by introduction of a diester linkage between antibody and a chelate in radioimmunodetection of tumor.}, author={C. H. Paik and K. Yokoyama and J C Reynolds and S. Quadri and C Y Min and S. Y. Shin and Patricia Maloney and Susan Mau Larson and R. C. Reba}, journal={Journal of nuclear medicine : official publication, Society of Nuclear Medicine}, year={1989}, volume={30 10}, pages={1693-701} }