Reduction of angiotensin A and alamandine vasoactivity in the rabbit model of atherogenesis: differential effects of alamandine and Ang(1-7).

@article{Habiyakare2014ReductionOA,
  title={Reduction of angiotensin A and alamandine vasoactivity in the rabbit model of atherogenesis: differential effects of alamandine and Ang(1-7).},
  author={Belthrand Habiyakare and Hiba Alsaadon and Michael L. Mathai and Alastair Hayes and Anthony Zulli},
  journal={International journal of experimental pathology},
  year={2014},
  volume={95 4},
  pages={
          290-5
        }
}
Novel treatments are necessary to reduce the burden of cardiovascular disease (CVD). Alamandine binds to MrgD and is reported to induce vasodilation via stimulation of endothelial nitric oxide synthase (eNOS), but its role in atherogenic blood vessels is yet to be determined. To determine the vasoactive role of alamandine and its precursor AngA in diseased aorta, New Zealand White rabbits were fed a diet containing 1% methionine + 0.5% cholesterol + 5% peanut oil for 4 weeks (MC, n = 5) or… CONTINUE READING
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