Reduction of amyloid-beta levels in mouse eye tissues by intra-vitreally delivered neprilysin.

Abstract

Amyloid-beta (Aβ) is a group of aggregation-prone, 38- to 43-amino acid peptides generated in the eye and other organs. Numerous studies suggest that the excessive build-up of low-molecular-weight soluble oligomers of Aβ plays a role in the progression of Alzheimer's disease and other brain degenerative diseases. Recent studies raise the hypothesis that… (More)
DOI: 10.1016/j.exer.2015.06.027

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