Reduction of all-trans-retinal limits regeneration of visual pigment in mice

  title={Reduction of all-trans-retinal limits regeneration of visual pigment in mice},
  author={John C Saari and Gregory G. Garwin and J. Preston Van Hooser and Krzysztof Palczewski},
  journal={Vision Research},
Absorption of photons by pigments in photoreceptor cells results in photoisomerization of the chromophore, 11-cis-retinal, to all-trans-retinal and activation of opsin. Photolysed chromophore is converted back to the 11-cis-configuration via several enzymatic steps in photoreceptor and retinal pigment epithelial cells. We investigated the levels of retinoids in mouse retina during constant illumination and regeneration in the dark as a means of obtaining more information about the rate-limiting… CONTINUE READING


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