Reduction of alcohol drinking and upregulation of opioid receptors by oral naltrexone in AA rats.

@article{Parkes2000ReductionOA,
  title={Reduction of alcohol drinking and upregulation of opioid receptors by oral naltrexone in AA rats.},
  author={Helen C. Parkes and John David Sinclair},
  journal={Alcohol},
  year={2000},
  volume={21 3},
  pages={215-21}
}
Rats of the high-drinking AA line were given 1 mg/kg naltrexone (NTX) or vehicle orally with a stress-free procedure just before 1 h of access to 10% ethanol daily for 8 days and again, 8 h later on the first 7 days. Forebrain homogenate binding studies using 0.03-6.00 nM [3H] naloxone were conducted from 1 to 4 days following treatment. NTX significantly suppressed alcohol intake, with the effect becoming progressively greater over days and continuing during the post-treatment period… CONTINUE READING

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