Reduction of alcohol's reinforcing and motivational properties by the positive allosteric modulator of the GABA(B) receptor, BHF177, in alcohol-preferring rats.

@article{Maccioni2009ReductionOA,
  title={Reduction of alcohol's reinforcing and motivational properties by the positive allosteric modulator of the GABA(B) receptor, BHF177, in alcohol-preferring rats.},
  author={Paola Maccioni and Mauro A. M. Carai and Klemens Kaupmann and S{\'e}bastien Guery and Wolfgang Froestl and Kimberly Anne Leite-Morris and Gian Luigi Gessa and Giancarlo Colombo},
  journal={Alcoholism, clinical and experimental research},
  year={2009},
  volume={33 10},
  pages={
          1749-56
        }
}
BACKGROUND The positive allosteric modulators of the GABA(B) receptor, CGP7930 and GS39783, have been found to reduce alcohol self-administration in alcohol-preferring rats. The present study was designed to assess the effect of the newly synthesized positive allosteric modulator of the GABA(B) receptor, BHF177, on alcohol's reinforcing and motivational properties in selectively bred Sardinian alcohol-preferring (sP) rats. METHODS sP rats were initially trained to respond on a lever [on a… CONTINUE READING
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GABAB receptor-positive modulators: enhancement of GABAB receptor agonist effects in vivo.

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