Reduction of acid sphingomyelinase activity in human fibroblasts induced by AY-9944 and other cationic amphiphilic drugs.

@article{Yoshida1985ReductionOA,
  title={Reduction of acid sphingomyelinase activity in human fibroblasts induced by AY-9944 and other cationic amphiphilic drugs.},
  author={Yoko Yoshida and Kei-ichiro Arimoto and Motohiko Sato and Norio Sakuragawa and Masakuni Arima and Eijiro Satoyoshi},
  journal={Journal of biochemistry},
  year={1985},
  volume={98 6},
  pages={1669-79}
}
AY-9944 (trans-1,4-bis(2-chlorobenzylaminoethyl)cyclohexane dihydrochloride), a cationic amphiphilic drug, caused a rapid, irreversible and dose-dependent reduction of acid sphingomyelinase activity in normal human fibroblasts without changing the activities of other lysosomal hydrolases tested. Examinations of activities against synthetic substrates and of the pH-dependency of sphingomyelinase in the drug-treated cells also suggested that the reduction of activity was specific to acid… CONTINUE READING

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