Reduction of a Markovian master equation for Na+ channel activation, and fast and slow inactivation within a neural or cardiac membrane


A nine state master equation for Na+ channel gating that describes the coupling between three activation sensors, a two-stage fast inactivation process and a slow inactivated state, may be reduced to a system of kinetic equations for a six state system. Assuming the activation sensors are independent and the activation variable m has a faster relaxation… (More)


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