Reduction of Pax9 gene dosage in an allelic series of mouse mutants causes hypodontia and oligodontia.

Abstract

Missing teeth (hypodontia and oligodontia) are a common developmental abnormality in humans and heterozygous mutations of PAX9 have recently been shown to underlie a number of familial, non-syndromic cases. Whereas PAX9 haploinsufficiency has been suggested as the underlying genetic mechanism, it is not known how this affects tooth development. Here we… (More)

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