Reduction of Orc6 Expression Sensitizes Human Colon Cancer Cells to 5-Fluorouracil and Cisplatin

@article{Gavin2008ReductionOO,
  title={Reduction of Orc6 Expression Sensitizes Human Colon Cancer Cells to 5-Fluorouracil and Cisplatin},
  author={Elaine J. Gavin and Bo Song and Yuan Mei Wang and Yaguang Xi and Jingfang Ju},
  journal={PLoS ONE},
  year={2008},
  volume={3},
  pages={9150 - 9155}
}
Previous studies from our group have shown that the expression levels of Orc6 were highly elevated in colorectal cancer patient specimens and the induction of Orc6 was associated with 5-fluorouracil (5-FU) treatment. The goal of this study was to investigate the molecular and cellular impact of Orc6 in colon cancer. In this study, we use HCT116 (wt-p53) and HCT116 (null-p53) colon cancer cell lines as a model system to investigate the impact of Orc6 on cell proliferation, chemosensitivity and… CONTINUE READING