Reduction of N(ω)-hydroxy-L-arginine by the mitochondrial amidoxime reducing component (mARC).

@article{Kotthaus2011ReductionON,
  title={Reduction of N(ω)-hydroxy-L-arginine by the mitochondrial amidoxime reducing component (mARC).},
  author={Juerke Kotthaus and Bettina Wahl and Antje Havemeyer and Joscha Kotthaus and D. Schade and Dieter Garbe-Sch{\"o}nberg and Ralf Mendel and Florian Bittner and B. E. P. Clement},
  journal={The Biochemical journal},
  year={2011},
  volume={433 2},
  pages={
          383-91
        }
}
NOSs (nitric oxide synthases) catalyse the oxidation of L-arginine to L-citrulline and nitric oxide via the intermediate NOHA (N(ω)-hydroxy-L-arginine). This intermediate is rapidly converted further, but to a small extent can also be liberated from the active site of NOSs and act as a transportable precursor of nitric oxide or potent physiological inhibitor of arginases. Thus its formation is of enormous importance for the nitric-oxide-generating system. It has also been shown that NOHA is… CONTINUE READING

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