Reduction of K+ efflux in cultured mouse fibroblasts, by mutation or by diuretics, permits growth in K+-deficient medium.

Abstract

The mouse fibroblastic cell line LM(TK-) is unable to grow at external K+ concentrations below a threshold value of 0.4 mM. At subthreshold K+ concentrations, LM(TK-) cells rapidly lose intracellular K+ and eventually lyse. We have analyzed the pathway primarily responsible for K+ efflux under these experimental conditions and reports its specific… (More)

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@article{Jayme1981ReductionOK, title={Reduction of K+ efflux in cultured mouse fibroblasts, by mutation or by diuretics, permits growth in K+-deficient medium.}, author={David W. Jayme and Edward A. Adelberg and C. W. Slayman}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={1981}, volume={78 2}, pages={1057-61} }