Reduction of Hippocampal Hyperactivity Improves Cognition in Amnestic Mild Cognitive Impairment

@article{Bakker2012ReductionOH,
  title={Reduction of Hippocampal Hyperactivity Improves Cognition in Amnestic Mild Cognitive Impairment},
  author={Arnold Bakker and Gregory L. Krauss and Marilyn S. Albert and Caroline L. Speck and Lauren R. Jones and Craig E. L. Stark and Michael A. Yassa and Susan Spear Bassett and Amy L. Shelton and Michela Gallagher},
  journal={Neuron},
  year={2012},
  volume={74},
  pages={467-474}
}
Elevated hippocampal activation is observed in conditions that confer risk for Alzheimer's disease, including amnestic mild cognitive impairment (aMCI). Studies in relevant animal models have indicated that overactivity in selective hippocampal circuits contributes to cognitive impairment. Here, we tested the effect of reducing hippocampal activation in aMCI. Under placebo treatment, hippocampal activation in the dentate gyrus/CA3 was elevated in aMCI patients compared to a healthy control… CONTINUE READING
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Revised Visual Retention Test 4th (New York: Psychological Corporation)

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