Reduction of Dizocilpine and Scopolamine-Induced Deficits in Avoidance Responding by SCH 54388, a Metabolite of Felbamate

@article{Smith1997ReductionOD,
  title={Reduction of Dizocilpine and Scopolamine-Induced Deficits in Avoidance Responding by SCH 54388, a Metabolite of Felbamate},
  author={R. D. Smith and M. Grzelak and V. Coffin},
  journal={Pharmacology Biochemistry and Behavior},
  year={1997},
  volume={58},
  pages={657-664}
}
  • R. D. Smith, M. Grzelak, V. Coffin
  • Published 1997
  • Medicine, Psychology
  • Pharmacology Biochemistry and Behavior
  • Felbamate (2-phenyl-1,3-propanediol dicarbamate) is a novel antiepileptic agent with a unique structure and mechanism of action, possibly involving binding sites at the N-methyl-D-aspartate receptor (NMDA) complex. A monocarbomate metabolite of felbamate (SCH 54388) was compared to felbamate using a mouse passive-avoidance paradigm (PAR). SCH 54388 was markedly free of toxic side effects up to doses of 300 mg/kg, sc. SCH 54388 reduced the deficit-producing effects of either scopolamine, a… CONTINUE READING
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