Reduction of Circulating Endothelial Cells in Peripheral Blood of ALS Patients

Abstract

BACKGROUND Amyotrophic Lateral Sclerosis (ALS) treatment is complicated by the various mechanisms underlying motor neuron degeneration. Recent studies showed that the blood-brain barrier (BBB) and blood-spinal cord barrier (BSCB) are compromised in an animal model of ALS due to endothelial cell degeneration. A later study demonstrated a loss of endothelium… (More)
DOI: 10.1371/journal.pone.0010614

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