Corpus ID: 37007211

Reduction of Chromium ( V 1 ) by Ascorbate Leads to Chromium-DNA Binding and DNA Strand Breaks in Vitrot

@inproceedings{Steams2001ReductionOC,
  title={Reduction of Chromium ( V 1 ) by Ascorbate Leads to Chromium-DNA Binding and DNA Strand Breaks in Vitrot},
  author={Diane M. Steams and L. Kennedy and K. Courtney and P. Giangrande and Laura and Phieffer and K. Wetterhahn},
  year={2001}
}
Chromium(V1) is a known human carcinogen which requires intracellular reduction for activation. Ascorbate (vitamin C) has been reported to function as a major reductant of Cr(V1) in animals and cell culture systems. The reaction of Cr(V1) with varying concentrations of ascorbate was studied under physiological conditions in vitro in order to determine the types of reactive intermediates produced and to evaluate the reactivity of these intermediates with DNA. Reactions of 1.8 mM Cr(V1) with 0-18… Expand