Reduction of CTL antipeptide response mediated by CD8+ cells whose class I MHC can bind the peptide.


Primary CTL responses can be generated in vitro against defined peptides in association with class I MHC molecules. We show here that if cells obtained from a 5-day MLR are also included in the cultures, the response is greatly reduced if the added cells both carry CD8 and can bind the peptide. Our interpretation is that the added MLR cells are acting as… (More)