Reduction of BiP levels decreases heterologous protein secretion in Saccharomyces cerevisiae.

@article{Robinson1996ReductionOB,
  title={Reduction of BiP levels decreases heterologous protein secretion in Saccharomyces cerevisiae.},
  author={Anne S. Robinson and J A Bockhaus and A C Voegler and K Dane Wittrup},
  journal={The Journal of biological chemistry},
  year={1996},
  volume={271 17},
  pages={10017-22}
}
Increased levels of the endoplasmic reticulum-resident protein folding chaperone BiP would be expected to either increase protein secretory capacity by improved solubilization of folding precursors or decrease secretory capacity by binding and retaining misfolded proteins. To address this question, the relationship between BiP levels and heterologous secretion in yeast was determined. A yeast strain was constructed in which BiP expression is tunable from 5 to 250% of wild-type levels, and this… CONTINUE READING
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