Reduction of B cell turnover in chronic lymphocytic leukaemia.

@article{Defoiche2008ReductionOB,
  title={Reduction of B cell turnover in chronic lymphocytic leukaemia.},
  author={Julien Defoiche and Christophe Debacq and Becca Asquith and Yan Zhang and Ars{\`e}ne Burny and Dominique Bron and Laurence Lagneaux and Derek C. Macallan and Lucas Willems},
  journal={British journal of haematology},
  year={2008},
  volume={143 2},
  pages={
          240-7
        }
}
Whether chronic lymphocytic leukaemia (CLL) is a latent or a proliferating disease has been intensively debated. Whilst the dogma that CLL results from accumulation of dormant lymphocytes is supported by the unresponsiveness of leukaemic cells to antigens and polyclonal activators, recent in vivo kinetic measurements indicate that B lymphocytes do divide at significant rates in CLL. However, an important and still unanswered question is whether CLL cells proliferate faster or slower compared… CONTINUE READING
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