Reduction of Arterial Stiffness by Exercise Training Is Associated with Increasing Plasma Apelin Level in Middle-Aged and Older Adults

@inproceedings{Fujie2014ReductionOA,
  title={Reduction of Arterial Stiffness by Exercise Training Is Associated with Increasing Plasma Apelin Level in Middle-Aged and Older Adults},
  author={Shumpei Fujie and Koji Sato and Eri Miyamoto-Mikami and Natsuki Hasegawa and Satoshi Fujita and Kiyoshi Sanada and Takafumi Hamaoka and Motoyuki Iemitsu},
  booktitle={PloS one},
  year={2014}
}
Aging-induced deterioration of arterial stiffness is decreased by regular exercise, and increased nitric oxide (NO) production participates in this effect. Apelin regulates endothelial NO synthase in endothelial cells, promoting NO production. However, the effect of aerobic exercise training on circulating apelin levels in healthy middle-aged and older adults remains unknown. Accordingly, this study aimed to clarify the effects of regular aerobic exercise on apelin concentrations in middle-aged… CONTINUE READING
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