Reduction in undesired sexual hair growth with Anandron in male‐to‐female transsexuals—experiences with a novel androgen receptor blocker

  title={Reduction in undesired sexual hair growth with Anandron in male‐to‐female transsexuals—experiences with a novel androgen receptor blocker},
  author={Henk Asscheman and I. J. G. Gooren and J. D. R. Peereboom‐Wynia},
  journal={Clinical and Experimental Dermatology},
The effect of Anandron, a novel non‐steroidal anti‐androgen, on the reduction in sexual hair growth of 14 malc‐to‐female transsexuals was investigated. Anandron (300 mg/day) alone for 8 weeks increased serum testosterone levels (mean: 19.2 ± 61 to 44.9±11.5 mmol/1) and serum oestradiol levels (mean: 0.08 ± 0.02 to 0.24±0.06 nmol/l). From Weeks 9 to 20, ethinyloestradiol (100 μg/day) was co‐administered. Hair growth scores, hair weight and the number of terminal hairs decreased significantly in… 
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Sparing a Testis during Vaginoplasty in Maleto‐Female Transsexuals: Does It Benefit Our Patients?

Because there are multiple reasons for castration, it is advised that bilateral orchidectomy be performed in the course of sex reassignment surgery for male‐to‐female transsexuals.

Pharmacodynamics and Pharmacokinetics of Nilutamide in Animal and Man

The pharmacodynamic and pharmacokinetic profiles are reviewed in this chapter and Nilutamide's structure is presented in Figure 1.



Effect of cyproterone acetate orally on hair density and diameter and endocrine factors in women with idiopathic hirsutism.

The effect of oral cyproterone acetate on hair density and diameter was studied in a clinically homogeneous group of 11 women with idiopathic hirsutism, and the possible influence on plasma androgen was studied.

A novel use of spironolactone: treatment of hirsutism.

  • G. ShapiroS. Evron
  • Medicine, Biology
    The Journal of clinical endocrinology and metabolism
  • 1980
The data suggest that the antiandrogenic properties of spironolactone render it a suitable agent in the treatment of hirsutism.

Relationship between plasma testosterone and dihydrotestosterone concentrations and male facial hair growth

Linear facial hair growth and the density of facial hair were measured by a photographic method and their relationship to plasma testosterone (T) and dihydrotestosterone (DHT) concentra tions was

Clinical assessment of body hair growth in women.

A method was developed for the semiquantitative assessment of body hair growth, and suitable for use in the study of clinical problems associated with hirsuties in women, and an “hormonal” score obtained by adding the gradings obtained from 9 of the 11 sites is being employed in clinical studies.

Lack of difference in testosterone metabolism between cultured skin fibroblasts of human adult males and females.

No differences in testosterone metabolism between fibroblasts from adult males and females were found, contrary to the report of Shanies et al (1).

Hair follicles and associated glands as androgen targets.

  • F. Ebling
  • Biology, Medicine
    Clinics in endocrinology and metabolism
  • 1986

Treatment of hirsutism and acne with cyproterone acetate.