Reduction in the structural changes of experimental osteoarthritis by a nitric oxide inhibitor.

@article{Pelletier1999ReductionIT,
  title={Reduction in the structural changes of experimental osteoarthritis by a nitric oxide inhibitor.},
  author={J. J. Pelletier and Dragan V. Jovanovic and Julio Cesar Lombaldo Fernandes and Pamela T. Manning and James R. Connor and Mark G. Currie and Johanne Martel-Pelletier},
  journal={Osteoarthritis and cartilage},
  year={1999},
  volume={7 4},
  pages={416-8}
}
OBJECTIVE To evaluate the in-vivo therapeutic efficacy of N -iminoethyl-L-Lysine (L-NIL), a selective inhibitor of inducible nitric oxide synthase (iNOS) in a dose response study, on the progression of lesions in the experimental osteoarthritic (OA) dog model. DESIGN The sectioning of the anterior cruciate ligament of the right stifle joint of mongrel dogs was done by a stab wound. Dogs were separated into experimental groups: Group 1 received no treatment, Groups 2, 3, and 4 received oral L… CONTINUE READING
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