Reduction in the size of layered double hydroxide nanoparticles enhances the efficiency of siRNA delivery.

  title={Reduction in the size of layered double hydroxide nanoparticles enhances the efficiency of siRNA delivery.},
  author={Min Chen and Helen M. Cooper and Ji Zhi Zhou and Perry F. Bartlett and Zhi Ping Xu},
  journal={Journal of colloid and interface science},
  volume={390 1},
Small interfering RNAs (siRNAs) are a potentially powerful new class of pharmaceutical drugs for many disease. However, the delivery of unprotected siRNAs is ineffective due to their susceptibility to degradation by ubiquitous nucleases under physiological conditions. Layered double hydroxide nanoparticles (LDHs) have been found to be efficient carriers of anionic drugs and nucleic acids. Our previous research has shown that LDHs (with the Z-average particle size of approximately 110 nm) can… CONTINUE READING
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