Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin.

@article{Knowler2002ReductionIT,
  title={Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin.},
  author={William C Knowler and Elizabeth Barrett-Connor and Sarah E. Fowler and Richard F. Hamman and John M Lachin and Elizabeth Anne Walker and David Matthew Nathan},
  journal={The New England journal of medicine},
  year={2002},
  volume={346 6},
  pages={
          393-403
        }
}
BACKGROUND Type 2 diabetes affects approximately 8 percent of adults in the United States. Some risk factors--elevated plasma glucose concentrations in the fasting state and after an oral glucose load, overweight, and a sedentary lifestyle--are potentially reversible. We hypothesized that modifying these factors with a lifestyle-intervention program or the administration of metformin would prevent or delay the development of diabetes. METHODS We randomly assigned 3234 nondiabetic persons with… CONTINUE READING

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