Reduction in the incidence of acute bronchitis by an oral Haemophilus influenzae vaccine in patients with chronic bronchitis in the highlands of Papua New Guinea.

@article{Lehmann1991ReductionIT,
  title={Reduction in the incidence of acute bronchitis by an oral Haemophilus influenzae vaccine in patients with chronic bronchitis in the highlands of Papua New Guinea.},
  author={Deborah Lehmann and K J Coakley and Christine Coakley and Veronica Spooner and Joel M. Montgomery and Antonis P. Michael and Ian Riley and Terry V. Smith and Robert Llewellyn Clancy and Allan Cripps},
  journal={The American review of respiratory disease},
  year={1991},
  volume={144 2},
  pages={
          324-30
        }
}
Following the administration of a standardized questionnaire, 62 adult patients with chronic bronchitis were enrolled into a double-blind controlled trial of an oral killed Haemophilus influenzae vaccine in the highlands of Papua New Guinea. A 3-day course of vaccine or placebo was given monthly for 3 consecutive months. Participants were monitored weekly over 12 months for acute exacerbations; early morning sputum specimens were collected monthly and during acute exacerbations. Density of… CONTINUE READING
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