Reduction in sympathetic nervous activity as a mechanism for hypotensive effect of propranolol

Abstract

THE β-adrenoceptor antagonist propranolol is an effective antihypertensive drug in man1 but it is not known how the fall in blood pressure is produced2. There is a decrease in plasma renin activity3 and in cardiac output immediately on starting propranolol therapy but neither of these effects can explain fully the hypotensive action of the drug which is… (More)
DOI: 10.1038/256440a0

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