Reduction in shear stress, activation of the endothelium, and leukocyte priming are all required for leukocyte passage across the blood--retina barrier.

@article{Xu2004ReductionIS,
  title={Reduction in shear stress, activation of the endothelium, and leukocyte priming are all required for leukocyte passage across the blood--retina barrier.},
  author={Heping Xu and Ayyakkannu Manivannan and Keith A. Goatman and Hui-Rong Jiang and Janet Liversidge and Peter F. Sharp and John V. Forrester and Isabel Joan Crane},
  journal={Journal of leukocyte biology},
  year={2004},
  volume={75 2},
  pages={
          224-32
        }
}
The passage of leukocytes across the blood-retina barrier at the early stages of an inflammatory reaction is influenced by a complex series of interactions about which little is known. In particular, the relationship between hydrodynamic factors, such as shear stress and leukocyte velocity, to the adherence and subsequent extravasation of leukocytes into the retina is unclear. We have used a physiological method, scanning laser ophthalmoscopy, to track labeled leukocytes circulating in the… CONTINUE READING
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