Reduction in reperfusion-induced myocardial necrosis in dogs by RheothRx injection (poloxamer 188 N.F.), a hemorheological agent that alters neutrophil function.

@article{Schaer1994ReductionIR,
  title={Reduction in reperfusion-induced myocardial necrosis in dogs by RheothRx injection (poloxamer 188 N.F.), a hemorheological agent that alters neutrophil function.},
  author={Gary L. Schaer and Tony L. Hursey and S L Abrahams and K Buddemeier and Bruce W. Ennis and E. Ren{\'e} Rodr{\'i}guez and James Hubbell and John Moy and Joseph E. Parrillo},
  journal={Circulation},
  year={1994},
  volume={90 6},
  pages={2964-75}
}
BACKGROUND Reperfusion after prolonged coronary artery occlusion may be followed by additional myocardial necrosis persisting for hours to days. Potential mechanisms include neutrophil-mediated injury and compromised flow within the microcirculation of the reperfused myocardium. Poloxamer 188 is a nonionic surfactant with beneficial hemorheological and neutrophil-inhibitory properties. The purpose of the present study was to determine if poloxamer 188 is capable of reducing the myocardial… CONTINUE READING

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