Reduction in neural-tube defects after folic acid fortification in Canada.

  title={Reduction in neural-tube defects after folic acid fortification in Canada.},
  author={Philippe De Wals and Fassiatou Tairou and Margot I. Van Allen and S H Uh and R Brian Lowry and Barbara Sibbald and Jane A. Evans and Michiel C. Van Den Hof and Pamela Zimmer and Marian Crowley and Bridget Fernandez and Nora S. Lee and Theophile Niyonsenga},
  journal={The New England journal of medicine},
  volume={357 2},
BACKGROUND In 1998, folic acid fortification of a large variety of cereal products became mandatory in Canada, a country where the prevalence of neural-tube defects was historically higher in the eastern provinces than in the western provinces. We assessed changes in the prevalence of neural-tube defects in Canada before and after food fortification with folic acid was implemented. METHODS The study population included live births, stillbirths, and terminations of pregnancies because of fetal… 

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