Reduction in myocardial collagen cross-linking parallels left ventricular dilatation in rat models of systolic chamber dysfunction.

@article{Woodiwiss2001ReductionIM,
  title={Reduction in myocardial collagen cross-linking parallels left ventricular dilatation in rat models of systolic chamber dysfunction.},
  author={Angela Jill Woodiwiss and Oupa J Tsotetsi and S C Sprott and Ellen Lancaster and Theofanie Mela and Eugene S. Chung and Timothy Edward Meyer and Gavin Robert Norton},
  journal={Circulation},
  year={2001},
  volume={103 1},
  pages={155-60}
}
BACKGROUND The transition from compensated left ventricular hypertrophy (LVH) to heart failure is associated with alterations in the myocardial interstitium. We hypothesized that LV dilatation is associated with modifications in collagen cross-linking. METHODS AND RESULTS We studied 2 rat models of LV dilatation: (1) pressure-overload hypertrophy with heart failure (POH-F) induced by suprarenal abdominal aortic banding and (2) LVH induced by 7 months of isoproterenol (ISO, 0.04 mg x kg(-1) x… CONTINUE READING

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