Reduction in membrane phosphatidylglycerol content leads to daptomycin resistance in Bacillus subtilis.


Daptomycin (DAP) is a cyclic lipopeptide that disrupts the functional integrity of the cell membranes of Gram-positive bacteria in a Ca(2+)-dependent manner. Here we present genetic, genomic, and phenotypic analyses of an evolved DAP-resistant isolate, Dap(R)1, from the model bacterium Bacillus subtilis 168. Dap(R)1 was obtained by serial passages with… (More)
DOI: 10.1128/AAC.01819-10


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