Reduction in maternal Polycomb levels contributes to transgenerational inheritance of a response to toxic stress in flies.

@article{Stern2014ReductionIM,
  title={Reduction in maternal Polycomb levels contributes to transgenerational inheritance of a response to toxic stress in flies.},
  author={Shay Stern and Orli Snir and Eran Mizrachi and Matana Galili and Inbal Zaltsman and Yoav Soen},
  journal={The Journal of physiology},
  year={2014},
  volume={592 11},
  pages={
          2343-55
        }
}
Transgenerational persistence of parental responses to environmental stimuli has been reported in various organisms, but the underlying mechanisms remain underexplored. In one of these reported examples, we have shown that exposure of fly larvae to G418 antibiotic leads to non-Mendelian inheritance of ectopic induction of certain developmental genes. Here we investigate if this inheritance involves changes in mRNA composition within the early, maternal-stage offspring embryos of exposed flies… CONTINUE READING

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