Reduction in intracellular calcium levels inhibits myoblast differentiation.

@article{Porter2002ReductionII,
  title={Reduction in intracellular calcium levels inhibits myoblast differentiation.},
  author={George A Porter and Ryan F Makuck and Scott A. Rivkees},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 32},
  pages={
          28942-7
        }
}
  • George A Porter, Ryan F Makuck, Scott A. Rivkees
  • Published in
    The Journal of biological…
    2002
  • Biology, Medicine
  • In myocytes, calcium plays an important role in intracellular signaling and contraction. However, the ability of calcium to modulate the differentiation of striated muscle cells is poorly understood. To examine this issue we studied C2C12 cells, which is a myoblast cell line that differentiates in vitro. First, we observed that the L-type calcium channel blockers nifedipine and verapamil effectively inhibited electrically induced calcium transients. Next, C2C12 cells were exposed to these… CONTINUE READING

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