Reduction in hippocampal cholinergic innervation is unrelated to recognition memory impairment in aged rhesus monkeys.

@article{Calhoun2004ReductionIH,
  title={Reduction in hippocampal cholinergic innervation is unrelated to recognition memory impairment in aged rhesus monkeys.},
  author={Michael E. Calhoun and Ying Mao and Jeffrey A Roberts and Peter R. Rapp},
  journal={The Journal of comparative neurology},
  year={2004},
  volume={475 2},
  pages={238-46}
}
Alterations in the basal forebrain cholinergic system have been widely studied in brain aging and Alzheimer's disease, but the magnitude of decline and relationship to cognitive impairment are still a matter of debate. The rhesus monkey (Macaca mulatta) provides a compelling model to study age-related memory decline, as the pattern of impairment closely parallels that observed in humans. Here, we used antibodies against the vesicular acetylcholine transporter and a new stereological technique… CONTINUE READING
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