Reduction in hexokinase II levels results in decreased cardiac function and altered remodeling after ischemia/reperfusion injury.

@article{Wu2011ReductionIH,
  title={Reduction in hexokinase II levels results in decreased cardiac function and altered remodeling after ischemia/reperfusion injury.},
  author={Rongxue Wu and Kirsten M A Smeele and Eugene Wyatt and Yoshihiko Ichikawa and Otto Eerbeek and Lin Yan Sun and Kusum Chawla and Markus W Hollmann and Varun Nagpal and Sami Heikkinen and Markku Laakso and Kentaro Jujo and John Andrew Wasserstrom and Coert J Zuurbier and Hossein Ardehali},
  journal={Circulation research},
  year={2011},
  volume={108 1},
  pages={60-9}
}
RATIONALE Cardiomyocytes switch substrate utilization from fatty acid to glucose under ischemic conditions; however, it is unknown how perturbations in glycolytic enzymes affect cardiac response to ischemia/reperfusion (I/R). Hexokinase (HK)II is a HK isoform that is expressed in the heart and can bind to the mitochondrial outer membrane. OBJECTIVE We sought to define how HKII and its binding to mitochondria play a role in cardiac response and remodeling after I/R. METHODS AND RESULTS We… CONTINUE READING

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