Reduction in hemoglobin-oxygen affinity results in the improvement of exercise capacity in mice with chronic heart failure.

@article{Watanabe2008ReductionIH,
  title={Reduction in hemoglobin-oxygen affinity results in the improvement of exercise capacity in mice with chronic heart failure.},
  author={Tetsuya Watanabe and Toshihiro Takeda and Shigemiki Omiya and Shungo Hikoso and Osamu Yamaguchi and Yuko Nakano and Yoshiharu Higuchi and Atsuko Nakai and Yusuke Abe and Yayoi Aki-Jin and Masayuki Taniike and Isamu Mizote and Yasushi Matsumura and Takahiko Shimizu and Kazuhiko Nishida and Kiyohiro Imai and Masatsugu Hori and Takuji Shirasawa and Kinya Otsu},
  journal={Journal of the American College of Cardiology},
  year={2008},
  volume={52 9},
  pages={779-86}
}
OBJECTIVES This study examined whether a reduction in hemoglobin-oxygen affinity improves exercise capacity in mice with heart failure. BACKGROUND Exercise intolerance is a major determinant of quality of life in patients with chronic heart failure. One of the major goals of the treatment for chronic heart failure is to improve quality of life. METHODS Four weeks after left coronary ligation, we transplanted bone marrow cells isolated from the transgenic mice expressing a hemoglobin variant… CONTINUE READING

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