Reduction in hMSH2 mRNA Levels by Premature Translation Termination (Implications for Mutation Screening in Hereditary Nonpolyposis Colorectal Cancer)


We have used single-strand conformationalpolymorphism (SSCP) and heteroduplex analysis to examineDNA from 50 colorectal carcinoma patients coming fromfamilies meeting the Amsterdam criteria for hereditary nonpolyposis colorectal cancer (HNPCC) orhaving developed colorectal carcinoma at age 45 oryounger. We identified mutations in 12 of thesepatients, with… (More)
DOI: 10.1023/A:1026609524482


3 Figures and Tables