Reduction in extrapulmonary tuberculosis in context of antiretroviral therapy scale-up in rural South Africa

@article{Hoogendoorn2017ReductionIE,
  title={Reduction in extrapulmonary tuberculosis in context of antiretroviral therapy scale-up in rural South Africa},
  author={J. Coosje Hoogendoorn and Lucy Ranoto and N Muditambi and Jean Railton and Mfana Perceive Maswanganyi and Helen E Struthers and James A McIntyre and Remco P. H. Peters},
  journal={Epidemiology and Infection},
  year={2017},
  volume={145},
  pages={2500 - 2509}
}
SUMMARY Scale-up of antiretroviral therapy (ART) for human immunodeficiency virus (HIV) infection has reduced the incidence of pulmonary tuberculosis (PTB) in South Africa. Despite the strong association of HIV infection with extrapulmonary tuberculosis (EPTB), the effect of ART on the epidemiology of EPTB remains undocumented. We conducted a retrospective record review of patients initiated on treatment for EPTB in 2009 (ART coverage <5%) and 2013 (ART coverage 41%) at four public hospitals in… 
Extrapulmonary tuberculosis in HIV-infected patients in rural Tanzania: The prospective Kilombero and Ulanga antiretroviral cohort
TLDR
Extrapulmonary tuberculosis was a frequent manifestation in this cohort of PLHIV and the diagnosis of EPTB in the absence of histopathology and mycobacterial culture remains challenging even with availability of Xpert® MTB/RIF.
Ocular Tuberculosis in HIV-infected Individuals
TLDR
Ocular manifestations within this group are distinct and unique investigational and therapeutic approaches are needed.
Child and adult spinal tuberculosis at tertiary hospitals in the Western Cape, South Africa: 4-year burden and trend
TLDR
It is suggested that Western Cape tertiary hospitals have experienced a substantial burden of spinal TB cases in recent years with a high proportion of severe presentation, particularly among children.
The Changing Global Epidemic of HIV and Ocular Disease
TLDR
The changing epidemic of ocular disease in HIV-infected patients warrants close monitoring and identification of interventions that can help reduce the imminent burden of disease.
Machine learning reveals that Mycobacterium tuberculosis genotypes and anatomic disease site impacts drug resistance and disease transmission among patients with proven extra-pulmonary tuberculosis
TLDR
It is hypothesized that poor anti-tuberculosis drug dosing might have a role in the development of resistance, and the majority of Mtb strains circulating in the Tshwane metropolis belongs to East Asian, Euro-American and East-African Indian lineages.
Machine-learning (ML) reveals that Mycobacterium tuberculosis genotypes and anatomic disease site impacts drug resistance and disease transmission among patients with proven extra-pulmonary tuberculosis
TLDR
Mtb strains circulating in the Tshwane metropolis belongs to East Asian, Euro-American and East-African Indian lineages, suggesting on-going EPTB transmission, and poor anti-tuberculosis drug dosing might have a role in the resistance.
Pleural Tuberculosis.
S0950268818002649jra 2107..2115
  • 2018
...
...

References

SHOWING 1-10 OF 52 REFERENCES
National Profile and Treatment Outcomes of Patients with Extrapulmonary Tuberculosis in Bénin
TLDR
Patients with EPTB generally do well in Bénin, although the TB Programme would benefit through more attention to accurate diagnosis and earlier start of ART in HIV-infected patients.
Site of extrapulmonary tuberculosis is associated with HIV infection.
  • I. Leeds, M. Magee, C. Kraft
  • Medicine
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2012
TLDR
Among patients hospitalized with EPTB, patients coinfected with HIV and low CD4 counts were more likely to have CNS/meningeal and disseminated disease and care for similar patients should include consideration of these forms of E PTB since they carry a high risk of death.
Epidemiology of extrapulmonary tuberculosis in Brazil: a hierarchical model
TLDR
Thirteen percent of patients diagnosed with TB in Brazil have only EPTB, and more effective diagnostic strategies and control measures are needed to reduce the number of cases of extrapulmonary tuberculosis in Brazil.
HIV-related tuberculosis in South Africa--clinical features and outcome.
  • D. Wilkinson, D. Moore
  • Medicine
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde
  • 1996
TLDR
It was found that HIV-positive patients with tuberculosis were three times more likely to fail to complete treatment than HIV-negative patients and poses an additional challenge to tuberculosis control programmes to maintain high case-holding rates among HIV-infected tuberculosis patients.
Effect of antiretroviral treatment on the risk of tuberculosis during South Africa's programme expansion
TLDR
ART was effective in preventing TB in HIV-infected patients with CD4+ cell counts below 350 cells/&mgr;l, but less so than previously estimated, and effectiveness increased each year.
Clinico-epidemiological profile of HIV/TB coinfected patients in Vadodara, Gujarat.
TLDR
The prevalence of tuberculosis in HIV-positive patients in this study was substantially higher than that reported in previous studies, however, this could be attributed to a selection and/or a diagnosis bias.
Extrapulmonary tuberculosis among adults: experience at Chris Hani Baragwanath Academic Hospital, Johannesburg, South Africa.
  • A. Karstaedt
  • Medicine
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde
  • 2013
TLDR
This retrospective cohort showed a high incidence of EPTB, most marked in the 25 - 44-year age group, and culture of extrapulmonary sites is of importance to confirm diagnosis of tuberculosis and to ensure antituberculosis drug susceptibility testing.
Exploring the Sociodemographic and Clinical Features of Extrapulmonary Tuberculosis in Saudi Arabia
TLDR
The Saudi population predominated with all forms of EPTB while immigrants showed no significant variations, and Saudi Arabia faces a serious threat from EPTBs, particularly to the central nervous system and gastrointestinal systems.
...
...