Reduction in exopolysaccharide viscosity as an aid to bacteriophage penetration through Pseudomonas aeruginosa biofilms.

@article{Hanlon2001ReductionIE,
  title={Reduction in exopolysaccharide viscosity as an aid to bacteriophage penetration through Pseudomonas aeruginosa biofilms.},
  author={Geoffrey William Hanlon and Stephen P. Denyer and Cedric J. Olliff and L J Ibrahim},
  journal={Applied and environmental microbiology},
  year={2001},
  volume={67 6},
  pages={2746-53}
}
To cause an infection, bacteriophages must penetrate the alginate exopolysaccharide of Pseudomonas aeruginosa to reach the bacterial surface. Despite a lack of intrinsic motility, phage were shown to diffuse through alginate gels at alginate concentrations up to 8% (wt/vol) and to bring about a 2-log reduction in the cell numbers in 20-day-old biofilms of P. aeruginosa. The inability of alginate to act as a more effective diffusional barrier suggests that phage may cause a reduction in the… CONTINUE READING

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