Reduction in endocannabinoid tone is a homeostatic mechanism for specific inhibitory synapses

@inproceedings{Kim2010ReductionIE,
  title={Reduction in endocannabinoid tone is a homeostatic mechanism for specific inhibitory synapses},
  author={Jimok Kim and Bradley E. Alger},
  booktitle={Nature Neuroscience},
  year={2010}
}
When chronic alterations in neuronal activity occur, network gain is maintained by global homeostatic scaling of synaptic strength, but the stability of microcircuits can be controlled by unique adaptations that differ from the global changes. It is not understood how specificity of synaptic tuning is achieved. We found that, although a large population of inhibitory synapses was homeostatically scaled down after chronic inactivity, decreased endocannabinoid tone specifically strengthened a… CONTINUE READING

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