Reduction in disease progression by inhibition of transforming growth factor α-CCL2 signaling in experimental posttraumatic osteoarthritis.

@article{Appleton2015ReductionID,
  title={Reduction in disease progression by inhibition of transforming growth factor α-CCL2 signaling in experimental posttraumatic osteoarthritis.},
  author={C Thomas G Appleton and Shirine E. Usmani and Michael A. Pest and Vasek Pitelka and John S. Mort and Frank M. Beier},
  journal={Arthritis & rheumatology},
  year={2015},
  volume={67 10},
  pages={
          2691-701
        }
}
OBJECTIVE Transforming growth factor α (TGFα) is increased in osteoarthritic (OA) cartilage in rats and humans and modifies chondrocyte phenotype. CCL2 is increased in OA cartilage and stimulates proteoglycan loss. This study was undertaken to test whether TGFα and CCL2 cooperate to promote cartilage degradation and whether inhibiting either reduces disease progression in a rat model of posttraumatic OA. METHODS Microarray analysis was used to profile expression of messenger RNA (mRNA) for… CONTINUE READING

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